CAMRT Radiography Practice Exam

Which condition may produce a radiographic appearance of a destructive lesion with irregular periosteal reaction?

1. Osteogenic sarcoma

2. Bone cyst

3. Osteoid osteoma

4. Gout

The correct answer is: Osteogenic sarcoma

Osteogenic sarcoma, also known as osteosarcoma, is a type of malignant bone tumor that is most commonly found in adolescents and young adults. It typically presents with a radiographic appearance characterized by a destructive lesion in the affected bone. This condition is known to cause an irregular periosteal reaction, which is a response of the periosteum (the connective tissue surrounding the bone) to the tumor’s aggressive growth. The irregularity of the periosteal reaction is a key feature observed in malignancies like osteogenic sarcoma, as the tumor invades surrounding tissues and stimulates the periosteum in a disorganized fashion. This can lead to the formation of layers of new bone that result in an irregular pattern, which is distinct from the more organized appearance seen in benign lesions or other conditions. In contrast, other options such as bone cysts typically produce well-defined lesions that are not characterized by aggressive periosteal reactions. Osteoid osteoma, while presenting as a bone lesion, usually manifests more clearly and with a more benign appearance. Gout primarily affects joint spaces and typically does not result in destructive bone lesions or periosteal reactions. Understanding the characteristics of osteogenic sarcoma helps in recognizing its radiographic features, particularly