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A low GFR and creatinine level typically indicate what?

  1. Increased kidney function

  2. Decreased kidney function

  3. Stable kidney function

  4. Optimal kidney function

The correct answer is: Decreased kidney function

A low Glomerular Filtration Rate (GFR) and elevated creatinine level are significant indicators of kidney function. The GFR is a critical measurement that assesses how well the kidneys are filtering blood, with lower values suggesting diminished filtering capability. Creatinine is a waste product produced by muscle metabolism, and it is typically cleared from the blood by the kidneys. When kidney function declines, creatinine levels rise due to the kidneys' reduced ability to filter and excrete it. Thus, when both the GFR is low and the creatinine level is elevated, it strongly points toward decreased kidney function, reflecting a potential renal impairment or failing ability to maintain normal physiological processes. Monitoring these parameters is essential in diagnosing and managing conditions that affect kidney health, such as acute kidney injury or chronic kidney disease. Understanding this relationship is crucial for making informed decisions regarding patient care and treatment options.